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Intrinsic connectivity of the human brain provides scaffold for tau aggregation in clinical variants of Alzheimer’s disease.

por jcdadm.website | ago 24, 2022 | Publication

Therriault J, Pascoal TA, Savard M, Mathotaarachchi S, Benedet AL, Chamoun M, Tissot C, Lussier FZ, Rahmouni N, Stevenson J, Qureshi MNI, Kang MS, Thomas É, Vitali P, Soucy JP, Massarweh G, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. Sci Transl Med. 2022 Aug...

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s disease.

por jcdadm.website | ago 10, 2022 | Publication

Ferrari-Souza JP, Ferreira PCL, Bellaver B, Tissot C, Wang YT, Leffa DT, Brum WS, Benedet AL, Ashton NJ, De Bastiani MA, Rocha A, Therriault J, Lussier FZ, Chamoun M, Servaes S, Bezgin G, Kang MS, Stevenson J, Rahmouni N, Pallen V, Poltronetti NM, Klunk WE, Tudorascu...
Study Challenges Dogma Behind Alzheimer’s Disease Drug Trials

Study Challenges Dogma Behind Alzheimer’s Disease Drug Trials

por Fernando Rigon | jul 19, 2022 | News

PITTSBURGH – Contrary to early studies, brain levels of enzymes that regulate DNA-folding drop as Alzheimer’s disease progresses, neuroscientists from the University of Pittsburgh, McGill University and Harvard University reported...

[11C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer’s disease.

por jcdadm.website | jul 19, 2022 | Publication

Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, Zürcher NR, Wang C, Hopewell R, Chakravarty M, Savard M, Thomas E, Mohaddes S, Farzin S, Salaciak...

Blood phospho-tau in Alzheimer disease: analysis, interpretation, and clinical utility.

por jcdadm.website | jul 1, 2022 | Publication

Karikari TK, Ashton NJ, Brinkmalm G, Brum WS, Benedet AL, Montoliu-Gaya L, Lantero-Rodriguez J, Pascoal TA, Suárez-Calvet M, Rosa-Neto P, Blennow K, Zetterberg H. Nat Rev Neurol. 2022 Jul;18(7):400-418. doi: 10.1038/s41582-022-00665-2. Epub 2022 May 18.

Quantification of SNAP-25 with mass spectrometry and Simoa: a method comparison in Alzheimer’s disease.

por jcdadm.website | jun 4, 2022 | Publication

Nilsson J, Ashton NJ, Benedet AL, Montoliu-Gaya L, Gobom J, Pascoal TA, Chamoun M, Portelius E, Jeromin A, Mendes M, Zetterberg H, Rosa-Neto P, Brinkmalm A, Blennow K. Alzheimers Res Ther. 2022 Jun 4;14(1):78. doi: 10.1186/s13195-022-01021-8.

18F-MK-6240 tau-PET in genetic frontotemporal dementia.

por jcdadm.website | jun 3, 2022 | Publication

Levy JP, Bezgin G, Savard M, Pascoal TA, Finger E, Laforce R, Sonnen JA, Soucy JP, Gauthier S, Rosa-Neto P, Ducharme S. Brain. 2022 Jun 3;145(5):1763-1772. doi: 10.1093/brain/awab392.

Mitochondrial complex I abnormalities underlie neurodegeneration and cognitive decline in Alzheimer’s disease.

por jcdadm.website | maio 1, 2022 | Publication

Terada T, Therriault J, Kang MS, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Poltronetti NM, Ottoy J, Arias JF, Bezgin G, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P. Eur J Neurol. 2022 May;29(5):1324-1334. doi: 10.1111/ene.15246....

Preclinical in vivo longitudinal assessment of KG207-M as a disease-modifying Alzheimer’s disease therapeutic.

por jcdadm.website | maio 1, 2022 | Publication

Kang MS, Shin M, Ottoy J, Aliaga AA, Mathotaarachchi S, Quispialaya K, Pascoal TA, Collins DL, Chakravarty MM, Mathieu A, Sandelius Å, Blennow K, Zetterberg H, Massarweh G, Soucy JP, Cuello AC, Gauthier S, Waterston M, Yoganathan N, Lessard E, Haqqani A, Rennie K,...

Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease.

por jcdadm.website | abr 1, 2022 | Publication

Cassidy CM, Therriault J, Pascoal TA, Cheung V, Savard M, Tuominen L, Chamoun M, McCall A, Celebi S, Lussier F, Massarweh G, Soucy JP, Weinshenker D, Tardif C, Ismail Z, Gauthier S, Rosa-Neto P. Neuropsychopharmacology. 2022 Apr;47(5):1128-1136. doi:...
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