Nature Medicine: Microglial Activation Is Involved in the Spread of Tau Tangles in Alzheimer’s Disease

por Fernando Rigon | nov 5, 2021 | News

Investigators including Pitt Psychiatry’s Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology), have published a paper in Nature Medicine investigating the correlation between microglial activation, abnormal tau tangles (a...

Publisher Correction: Microglial activation and tau propagate jointly across Braak stages.

por jcdadm.website | nov 1, 2021 | Publication

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Nat Med....

Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease.

por jcdadm.website | out 1, 2021 | Publication

Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, Soucy JP, Cuello AC, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer’s Disease...

APOEε4 potentiates the relationship between amyloid-β and tau pathologies.

por jcdadm.website | out 1, 2021 | Publication

Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Savard M, Chamoun M, Thomas E, Kang MS, Lussier F, Tissot C, Soucy JP, Massarweh G, Rej S, Saha-Chaudhuri P, Poirier J, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Psychiatry. 2021...

Amyloid-dependent and amyloid-independent effects of Tau in individuals without dementia.

por jcdadm.website | out 1, 2021 | Publication

Therriault J, Pascoal TA, Sefranek M, Mathotaarachchi S, Benedet AL, Chamoun M, Lussier FZ, Tissot C, Bellaver B, Lukasewicz PS, Zimmer ER, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Ann Clin Transl Neurol. 2021...

Microglial activation and tau propagate jointly across Braak stages.

por jcdadm.website | set 1, 2021 | Publication

Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, Savard M, Lussier FZ, Tissot C, Karikari TK, Ottoy J, Mathotaarachchi S, Stevenson J, Massarweh G, Schöll M, de Leon MJ, Soucy JP, Edison P, Blennow K, Zetterberg H, Gauthier S, Rosa-Neto P. Nat Med....

Brain Tissue Inflammation Drives Alzheimer’s Disease

por Fernando Rigon | ago 26, 2021 | News

PITTSBURGH – Neuroinflammation is the key driver of the spread of pathologically misfolded proteins in the brain and causes cognitive impairment in patients with Alzheimer’s disease, researchers from the University of Pittsburgh School of...

A multicenter comparison of [18F]flortaucipir, [18F]RO948, and [18F]MK6240 tau PET tracers to detect a common target ROI for differential diagnosis.

por jcdadm.website | jul 1, 2021 | Publication

Leuzy A, Pascoal TA, Strandberg O, Insel P, Smith R, Mattsson-Carlgren N, Benedet AL, Cho H, Lyoo CH, La Joie R, Rabinovici GD, Ossenkoppele R, Rosa-Neto P, Hansson O. Eur J Nucl Med Mol Imaging. 2021 Jul;48(7):2295-2305. doi: 10.1007/s00259-021-05401-4. Epub 2021 May...

Pitt Psychiatry Hosts a Tremendous Research “Half” Day

por Fernando Rigon | jun 14, 2021 | News

On June 9, 2021, the Department of Psychiatry held its 2nd virtual Research Day, featuring presentations on health equity research, a speed dat(a)ing session, a keynote address, and honors and awards.  The event was billed as a Research “Half” Day, as we hope and...

Association of plasma P-tau181 with memory decline in non-demented adults.

por jcdadm.website | jun 14, 2021 | Publication

Therriault J, Benedet AL, Pascoal TA, Lussier FZ, Tissot C, Karikari TK, Ashton NJ, Chamoun M, Bezgin G, Mathotaarachchi S, Gauthier S, Saha-Chaudhuri P, Zetterberg H, Blennow K, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Brain Commun. 2021 Jun...