A multicentre validation study of the diagnostic value of plasma neurofilament light.

por jcdadm.website | jun 7, 2021 | Publication

Ashton NJ, Janelidze S, Al Khleifat A, Leuzy A, van der Ende EL, Karikari TK, Benedet AL, Pascoal TA, Lleó A, Parnetti L, Galimberti D, Bonanni L, Pilotto A, Padovani A, Lycke J, Novakova L, Axelsson M, Velayudhan L, Rabinovici GD, Miller B, Pariante C, Nikkheslat N,...

Interactive rather than independent effect of APOE and sex potentiates tau deposition in women.

por jcdadm.website | jun 7, 2021 | Publication

Wang YT, Pascoal TA, Therriault J, Kang MS, Benedet AL, Savard M, Tissot C, Lussier FZ, Arias JF, Mathotaarachchi S, Rajah MN, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Brain Commun. 2021 Jun 7;3(2):fcab126. doi: 10.1093/braincomms/fcab126....

Pitt Psychiatry Investigators Report New Findings in Alzheimer’s Disease and Dementia & Late-Life Depression Research

por Fernando Rigon | maio 17, 2021 | News

Acta Neuropathologica: Plasma P-Tau231, A New Biomarker for Incipient Alzheimer’s Disease Pathology Scientists including Tharick Pascoal, MD, PhD (Assistant Professor of Psychiatry and Neurology) from Pitt Psychiatry have published the discovery...

What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies.

por jcdadm.website | maio 10, 2021 | Publication

Villemagne VL, Lopresti BJ, Doré V, Tudorascu D, Ikonomovic MD, Burnham S, Minhas D, Pascoal TA, Mason NS, Snitz B, Aizenstein H, Mathis CA, Lopez O, Rowe CC, Klunk WE, Cohen AD. J Nucl Med. 2021 May 10;62(5):614-619. doi: 10.2967/jnumed.120.245423. Epub 2020 Dec...

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology.

por jcdadm.website | maio 1, 2021 | Publication

Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G, Snellman A, Schöll M, Troakes C, Hye A, Gauthier S, Vanmechelen E, Zetterberg H, Rosa-Neto P, Blennow K. Acta Neuropathol. 2021 May;141(5):709-724. doi: 10.1007/s00401-021-02275-6. Epub...

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease.

por jcdadm.website | abr 28, 2021 | Publication

Lyra E Silva NM, Gonçalves RA, Pascoal TA, Lima-Filho RAS, Resende EPF, Vieira ELM, Teixeira AL, de Souza LC, Peny JA, Fortuna JTS, Furigo IC, Hashiguchi D, Miya-Coreixas VS, Clarke JR, Abisambra JF, Longo BM, Donato J Jr, Fraser PE, Rosa-Neto P, Caramelli P, Ferreira...

Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer’s disease.

por jcdadm.website | abr 26, 2021 | Publication

Terada T, Therriault J, Kang MSP, Savard M, Pascoal TA, Lussier F, Tissot C, Wang YT, Benedet A, Matsudaira T, Bunai T, Obi T, Tsukada H, Ouchi Y, Rosa-Neto P. Mol Neurodegener. 2021 Apr 26;16(1):28. doi: 10.1186/s13024-021-00448-1.

Plasma levels of phosphorylated tau 181 are associated with cerebral metabolic dysfunction in cognitively impaired and amyloid-positive individuals.

por jcdadm.website | abr 15, 2021 | Publication

Lussier FZ, Benedet AL, Therriault J, Pascoal TA, Tissot C, Chamoun M, Mathotaarachchi S, Savard M, Ashton NJ, Karikari TK, Rodriguez JL, Snellman A, Bezgin G, Kang MS, Fernandez Arias J, Wang YT, Gauthier S, Zetterberg H, Blennow K, Rosa-Neto P; Alzheimer’s Disease...

Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer’s disease.

por jcdadm.website | mar 31, 2021 | Publication

Tissot C, Therriault J, Pascoal TA, Chamoun M, Lussier FZ, Savard M, Mathotaarachchi SS, L Benedet A, Thomas EM, Parsons M, Nasreddine Z, Rosa-Neto P, Gauthier S. Alzheimers Dement (N Y). 2021 Mar 31;7(1):e12154. doi: 10.1002/trc2.12154. eCollection 2021.

Plasma pTau181 predicts cortical brain atrophy in aging and Alzheimer’s disease.

por jcdadm.website | mar 29, 2021 | Publication

Tissot C, L Benedet A, Therriault J, Pascoal TA, Lussier FZ, Saha-Chaudhuri P, Chamoun M, Savard M, Mathotaarachchi SS, Bezgin G, Wang YT, Fernandez Arias J, Rodriguez JL, Snellman A, Ashton NJ, Karikari TK, Blennow K, Zetterberg H, De Villers-Sidani E, Huot P,...