Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment.

por jcdadm.website | jun 21, 2020 | Publication

Pascoal TA, Therriault J, Mathotaarachchi S, Kang MS, Shin M, Benedet AL, Chamoun M, Tissot C, Lussier F, Mohaddes S, Soucy JP, Massarweh G, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12037....

Blood phosphorylated tau 181 as a biomarker for Alzheimer’s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts.

por jcdadm.website | maio 1, 2020 | Publication

Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, Chamoun M, Savard M, Kang MS, Therriault J, Schöll M, Massarweh G, Soucy JP, Höglund K, Brinkmalm G, Mattsson N, Palmqvist S, Gauthier S, Stomrud E, Zetterberg H, Hansson O, Rosa-Neto P,...

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β.

por jcdadm.website | abr 1, 2020 | Publication

Therriault J, Benedet AL, Pascoal TA, Mathotaarachchi S, Chamoun M, Savard M, Thomas E, Kang MS, Lussier F, Tissot C, Parsons M, Qureshi MNI, Vitali P, Massarweh G, Soucy JP, Rej S, Saha-Chaudhuri P, Gauthier S, Rosa-Neto P. JAMA Neurol. 2020 Apr 1;77(4):470-479. doi:...

Modeling Associations Between Pathological Pathways in the Progression of Alzheimer’s Disease Using PET Imaging

por Fernando Rigon | fev 10, 2020 | News

Dr. Tharick Pascoal is a clinical neurologist and a post-doctoral fellow at Douglas Hospital, McGill University in Montreal, Canada. Through his research, he aims to develop therapeutic targets for neurodegenerative diseases through the identification of biomarkers of...

Suicidal ideation is common in autosomal dominant Alzheimer’s disease at-risk persons.

por jcdadm.website | jan 1, 2020 | Publication

Ng KP, Richard-Devantoy S, Bertrand JA, Jiang L, Pascoal TA, Mathotaarachchi S, Therriault J, Yatawara C, Kandiah N, Greenwood CMT, Rosa-Neto P, Gauthier S; Dominantly Inherited Alzheimer Network. Int J Geriatr Psychiatry. 2020 Jan;35(1):60-68. doi: 10.1002/gps.5215....

Mild behavioral impairment is associated with β-amyloid but not tau or neurodegeneration in cognitively intact elderly individuals.

por jcdadm.website | jan 1, 2020 | Publication

Lussier FZ, Pascoal TA, Chamoun M, Therriault J, Tissot C, Savard M, Kang MS, Mathotaarachchi S, Benedet AL, Parsons M, Qureshi MNI, Thomas ÉM, Shin M, Dion LA, Massarweh G, Soucy JP, Tsai IH, Vitali P, Ismail Z, Rosa-Neto P, Gauthier S. Alzheimers Dement. 2020...

Rostral-Caudal Hippocampal Functional Convergence Is Reduced Across the Alzheimer’s Disease Spectrum.

por jcdadm.website | dez 1, 2019 | Publication

Therriault J, Wang S, Mathotaarachchi S, Pascoal TA, Parent M, Beaudry T, Shin M, Al B, Kang MS, Ng KP, Dansereau C, Park MTM, Fonov V, Carbonell F, Zimmer E, Chakravarty MM, Bellec P, Gauthier S, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol...

Vascular retinal biomarkers improves the detection of the likely cerebral amyloid status from hyperspectral retinal images.

por jcdadm.website | out 14, 2019 | Publication

Sharafi SM, Sylvestre JP, Chevrefils C, Soucy JP, Beaulieu S, Pascoal TA, Arbour JD, Rhéaume MA, Robillard A, Chayer C, Rosa-Neto P, Mathotaarachchi SS, Nasreddine ZS, Gauthier S, Lesage F. Alzheimers Dement (N Y). 2019 Oct 14;5:610-617. doi:...

Plasma neurofilament light associates with Alzheimer’s disease metabolic decline in amyloid-positive individuals.

por jcdadm.website | set 27, 2019 | Publication

Benedet AL, Ashton NJ, Pascoal TA, Leuzy A, Mathotaarachchi S, Kang MS, Therriault J, Savard M, Chamoun M, Schöll M, Zimmer ER, Gauthier S, Labbe A, Zetterberg H, Blennow K, Neto PR. Alzheimers Dement (Amst). 2019 Sep 27;11:679-689. doi: 10.1016/j.dadm.2019.08.002....

Regional Amyloid-β Load and White Matter Abnormalities Contribute to Hypometabolism in Alzheimer’s Dementia.

por jcdadm.website | jul 1, 2019 | Publication

Schilling LP, Pascoal TA, Zimmer ER, Mathotaarachchi S, Shin M, de Mello Rieder CR, Gauthier S, Palmini A, Rosa-Neto P; Alzheimer’s Disease Neuroimaging Initiative. Mol Neurobiol. 2019 Jul;56(7):4916-4924. doi: 10.1007/s12035-018-1405-1. Epub 2018 Nov...